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KMID : 0644120130260030001
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Journal of Oriental Gynecology
2013 Volume.26 No. 3 p.1 ~ p.17
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The Effect of Samul-tanggahyangbuja on Depression and Learning on Repeated Stress in Ovariectomized Rats
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Lee Soon-Yee
Kim Song-Baek
Seo Yun-Jung
Choi Chang-Min
Cho Han-Baek
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Abstract
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Objectives: In this research, the effect of samul-tanggahyangbuja on depression and learning in ovariectomized rats subjected to repetitive stress were assessed. Samul-tanggahyangbuja is the prescription consisting of Samul-tang and Cyperi Rhizoma.
Methods: Ovariectomized rats were repeatedly stressed over a 2-week period. After being orally medicated with samul-tanggahyangbuja (100 or 400 mg/kg), rats performed the Morris water maze test and forced swimming test, and social exploration was assessed in a behavior test. As well, sucrose intake was measured and measurements of blood serum corticosterone and the change of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in blood samples were made.
Results:
1. In the Morris water maze test, rats medicated with 100 mg samul-tanggahyangbuja mastered the maze in a shorter time on the 4th day in comparison with the control group, while rats medicated with 400 mg samul-tanggahyangbuja mastered the maze more quickly (p<0.05 on the 3rd day ; p<0.01 on the 4th day, as compared to control).
2. Immobility time in the forced swimming test was significantly decreased in rats receiving 400 mg samul-tanggahyangbuja compared with the control group (p<0.05).
3. Sucrose intake and active social behavior of rats receiving 400 mg samultanggahyangbuja were markedly increased in comparison with the control group (p<0.01).
4. Blood serum corticosterone measurements revealed decreased blood serum corticosterone level after medicating with samul-tanggahyangbuja. But it was not statistically significant.
5. Treatment with either dose of samul-tanggahyangbuja significantly reduced IL-1β and TNF-α (p<0.05).
Conclusions: These results suggest that samul-tanggahyangbuja possesses the anti-depressant and cognitive-enhancing activities related to menopause.
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KEYWORD
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Menopausal depression, Samul-tanggahyangbuja, Morris Water Maze Test, Forced Swimming Test, Corticosterone, Cytokine
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